She was originally trained as technician, later become a MD (Medical School Hannover, Germany and University of Bern, Inselspital, Switzerland) specializing in Allergology and clinical Immunology. She continued to work during her study and later in the laboratory, and trained in laboratory medicine and holds degrees in Allergology/clinical Immunology (FMH) as well as in labopratory medicine (clinical Immunology, FAMH). She published both in clinical science as well as in immunology and allergology She is cofounder of ADR-AC and responsible for the coordination of clinical and laboratory work at ADR-AC. In addition, she manages human resources at ADR-AC.
She is coordinating the T cell research at ADR-AC. She has gained a lot of experience in studying the immunology of the multiple drug hypersensitivity syndrome, and evaluated the role of regulatory T cells (Treg) in drug hypersensitivity. She is presently investigating these role of herpes virus infections in drug hypersensitivity. In addition to these focused projects, she is also coordinating the extensive pool of patients with different forms of drug hypersensitivity willing to donate blood for further research.
He is investigating the role of basophil in immediate, IgE mediated reactions as well as their potential use in diagnostic tests. He established together with Oliver Hausmann, MD the basophil actvation test (BAT) with protein antigens like hymenoptera venoms, then the use of BAT to detect antibodies to Fc-IgεRI or IgE in chronic idiopathic urticaria (both tests are already offered by ADR-AC). A special emphasis is put on the optimal conditions to passively sensitize basophils with IgE from serum of patients with drug induced anaphylaxis, as this would greatly facilitate the diagnosis. He is now investigating the use of BAT in immediate drug hypersensitivity and its use in analyzing transfusion reactions to biologicals.
She studied biology at the Faculty of Food Technology and Biotechnology, Department of Biochemical Engineering in Zagreb. She got acquainted with industry having research positions in various small companies. From 2006 to 2009 she did her PhD thesis in the group of Prof. Clemens Dahinden in the Institute of Immunology, Inselspital, University of Bern. She joined ADR-AC in 2-2010, where she is responsibel for the technical improvements of diagnostic assays. She is involved in routine applications of basophil activation tests, where her great experience helps to improve these assays and to make them usable for drug allergy diagnosis. Moreover, she is performing various T cell based assays to improve the diagnosis of T cell reactions to drugs in Stevens-Johnson patients.
He is a guest scientist from Thailand, who works in the refinement of in vitro diagnosis of drug allergies, in particular for delayed reactions. He has extensive experience various in vitro assays for lymphocyte functions and represents a valuable support of our research team. He is studying possible improvements and simplifications of the lymphocyte transformation tests.
He has studied medicine in Innsbruck, Austria, trained as immunologist in Vienna, Austria and at the NIH/Bethesda/USA. He became an internist and clinical immunologist by training in the division of clinical immunology at the Medical School Hannover, Germany, where he soon became a lecturer in clinical Immunology. Since 1984 he works in Bern, Switzerland, where he is professor for clinical immunology since 1989 and head of the allergy division. He focused his research on drug hypersensitivity, where he co-authored > 150 publications. He recently edited the book: Drug Hypersensitivity, Karger 2007. He is the founder of ADR-AC and will serve as advisor for clinical questions and in planning the tests and experiments. He is also acting as consultant for presumed drug allergic reactions in phase 1-3 studies.